Tepotinib vs Standard Treatment in Patients With Advanced MET Exon 14 Mutated Non-Small Cell Lung Cancer Previously Treated

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

133

Participants

Timeline

Start Date

July 15, 2025

Primary Completion Date

March 15, 2028

Study Completion Date

July 15, 2028

Conditions
Advanced Non Small Cell Lung CancerMET Exon 14 Mutation
Interventions
DRUG

Tepotinib

Tepotinib will be given orally once daily at the dose of 500mg of tepotinib hydrochloride hydrate.

DRUG

Pemetrexed (Alimta)

500 mg/m² every 3 weeks

DRUG

Vinorelbine

25-30 mg/m² D1, D8, every 3 weeks

DRUG

Gemcitabine alone

1250 mg/m² D1, D8, every 3 weeks

DRUG

Docetaxel

75 mg/m² every 3 weeks

DRUG

Paclitaxel

90 mg/m² D1, D8, D15 every 4 weeks If bevacizumab added: 10 mg/kg D1, D15 every 4 weeks

DRUG

Pembrolizumab

200 mg every 3 weeks

DRUG

Nivolumab

240 mg every 2 weeks

DRUG

Atezolizumab

1200 mg every 3 weeks

Trial Locations (29)

21000

Dijon - Centre Georges-François Leclerc, Dijon

44805

Institut de Cancérologie de l'Ouest - René Gauducheau, Saint-Herblain

54500

Nancy - CHU, Vandœuvre-lès-Nancy

63000

Strasbourg - NHC, Strasbourg

64000

Centre Hospitalier Général - Pau, Pau

69373

Centre Léon Bérard, Lyon

75014

AP-HP Hôpital Cochin, Paris

75970

AP-HP Hôpital Tenon, Paris

83000

Toulon - CHI, Toulon

89100

Sens - CH, Sens

94000

Centre Hospitalier Intercommunal de Créteil, Créteil

Unknown

Besançon - CHU, Besançon

Bordeaux - Institut Bergonie, Bordeaux

Brest - CHU, Brest

Caen - CRLCC, Caen

Grenoble - CHU, Grenoble

CHD Vendée, La Roche-sur-Yon

Le Mans - CHG, Le Mans

CHRU de Lille, Lille

Institut Paoli Calmette, Marseille

Marseille - APHM, Marseille

Montpellier - CHU, Montpellier

Centre Antoine Lacassagne, Nice

Paris - APHP Bichat, Paris

Bordeaux - CHU, Pessac

CHU Toulouse, Toulouse

CHRU de Tours, Tours

CH de Valence, Valence

Gustave Roussy, Villejuif

All Listed Sponsors
lead

Intergroupe Francophone de Cancerologie Thoracique

OTHER

NCT06908993 - Tepotinib vs Standard Treatment in Patients With Advanced MET Exon 14 Mutated Non-Small Cell Lung Cancer Previously Treated | Biotech Hunter | Biotech Hunter