610
Participants
Start Date
April 15, 2025
Primary Completion Date
January 31, 2029
Study Completion Date
December 31, 2029
Bedaquiline (B)
The initial dose of bedaquiline is 400 mg daily for 2 weeks, followed by 200 mg three times a week.
Sitafloxacin (S)
200mg once daily
Linezolid (L)
600mg once daily
Pyrazinamide (Z)
20-30 mg/kg/day; 1000 mg for patients weighing \<50 kg, 1500 mg for patients weighing ≥50 kg but \<75 kg, and 2000 mg for patients weighing ≥75 kg.
Isoniazid (H)
4-6 mg/kg once daily, 300 mg once daily
Rifampicin (R)
8-12 mg/kg once daily, 450 mg for patients weighing \<50 kg, 600 mg for patients weighing ≥50 kg but \<75 kg, and 750 mg for patients weighing ≥75 kg.
Ethambutol (E)
15-25 mg/kg once daily, 750 mg once daily
Moxifloxacin (M)
400mg once daily
Pretomanid (Pa)
200mg once daily
First Affiliated Hospital of Zhejiang University
OTHER
Beijing Chest Hospital of Capital Medical University
UNKNOWN
Shenyang Tenth People's Hospital
OTHER
The Sixth People's Hospital of the Xinjiang Uygur Autonomous Region
UNKNOWN
The Fourth Hospital of Inner Mongolia Autonomous Region
UNKNOWN
Guizhou Aerospace Hospital
UNKNOWN
Shenzhen Third People's Hospital
OTHER