Intra-Arterial Tenecteplase to Improve the Microvascular Hemodynamics After Mechanical Thrombectomy

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

November 15, 2025

Primary Completion Date

September 30, 2026

Study Completion Date

September 30, 2026

Conditions
Acute Ischemic Stroke From Large Vessel Occlusion
Interventions
DRUG

intra-arterial tenecteplase administration

Patients will receive a single dose of tenecteplase, administered intra-arterially after successful large vessel recanalization. The treatment will be administered via intra-arterial catheter in the distal M1 segment of the middle cerebral artery (distal to lenticulostriates).

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

lead

University of Pennsylvania

OTHER