Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

October 15, 2025

Primary Completion Date

May 31, 2027

Study Completion Date

May 31, 2028

Conditions
Orthopedic Trauma Surgery PatientsPostoperative PainOpioid UseDepressionPost-traumatic Stress Disorder (PTSD)
Interventions
DRUG

Ketamine

Participants in this group will receive a single intravenous (IV) dose of ketamine at 0.5 mg/kg, administered within 30 minutes of anesthesia induction during surgical fixation for musculoskeletal trauma. The purpose of the intervention is to evaluate ketamine's effect on postoperative pain, opioid consumption, and psychological recovery, including symptoms of depression and post-traumatic stress disorder (PTSD).

DRUG

standard general anesthesia

Participants in this group will receive standard general anesthesia during surgical fixation for musculoskeletal trauma. No ketamine will be administered. This group serves as a comparison to evaluate the effects of ketamine on pain, opioid use, and psychological recovery.

Trial Locations (2)

79415

Texas Tech University Health Sciences Center Lubbock, Lubbock

University Medical Center, Lubbock

All Listed Sponsors
lead

Texas Tech University Health Sciences Center

OTHER