A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

April 21, 2025

Primary Completion Date

May 1, 2029

Study Completion Date

May 1, 2029

Conditions
Lupus Erythematosus, Systemic
Interventions
BIOLOGICAL

AZD0120

Single infusion of AZD0120 on visit DAY 1 after completing required lymphodepleting chemotherapy..

DRUG

Cyclophosphamide

Lymphodepletion - specified dose prior to receiving AZD0120

DRUG

Fludarabine

Lymphodepletion - specified dose prior to receiving AZD0120

Trial Locations (5)

10032

RECRUITING

Research Site, New York

20892

NOT_YET_RECRUITING

Research Site, Bethesda

98104

NOT_YET_RECRUITING

Research Site, Seattle

98195

NOT_YET_RECRUITING

Research Site, Seattle

13202-2240

NOT_YET_RECRUITING

Research Site, Syracuse

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY