Study of Pazopanib Combined With Palbociclib for Refractory Solid Tumors With Co-amplified in the 11q13(FGF3/4/19/CCND1)

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

65

Participants

Timeline

Start Date

November 27, 2024

Primary Completion Date

December 1, 2025

Study Completion Date

December 31, 2025

Conditions
Solid Tumor, AdultNext-generation SequencingPrecision Medicine
Interventions
DRUG

Pazopanib Oral Tablet

Orally administered once daily (100mg)for 21 consecutive days, followed by a 7-day cessation of medication; Every 28 days is a treatment cycle.

DRUG

Palbociclib

Oral treatment once a day, with a cycle of 28 days. In the safety introduction section, the initial dose of pazopanib is 400mg, and in the dose escalation queue, the dose of pazopanib is 600mg.

Trial Locations (1)

300211

RECRUITING

Tianjin Medical Unversity Second Hospital, Tianjin

All Listed Sponsors
lead

Tianjin Medical University Second Hospital

OTHER