174
Participants
Start Date
April 1, 2025
Primary Completion Date
June 30, 2026
Study Completion Date
September 30, 2026
Esketamine group
Patients in the esketamine group will receive intravenous infusion of esketamine besides PRF+standardized treatment.The formula will be intravenous infusion of 0.5mg/kg of esketamine diluted in 50 mL normal saline, starting with intravenous injection of 10 mg of esketamine for 1 minute, and maintaining a dose 8 mg/h.The infusion rate will be adjusted the parameter according to the tolerance of the patients
PRF group
Patients in the control group will receive PRF+standardized treatment
RECRUITING
Beijing Tiantan Hospital, Beijing
Beijing Xiaotangshan Hospital
OTHER
The First Hospital of Fangshan District,Beijing
OTHER
Beijing Ditan Hospital
OTHER
Hengshui People's Hospital
OTHER
Beijing Tiantan Hospital
OTHER