Evaluating the Long-term Safety and Tolerability of Imatinib in Patients With Lymphangioleiomyomatosis (LAM)

PHASE1RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

October 31, 2025

Primary Completion Date

December 31, 2026

Study Completion Date

March 31, 2027

Conditions
Lymphangioleiomyomatosis (LAM)Lymphangioleiomyomatosis
Interventions
DRUG

Imatimib Mesylate

Participants will take Imatinib mesylate (imatinib), an FDA approved drug for leukemia, orally 400 mg (twice daily)

DRUG

Placebo

Placebo will be administered in the same dosage and manner as the study drug. The placebo looks like the study drug but contains no active ingredients.

Trial Locations (2)

10032

RECRUITING

Columbia University Irving Medical Center, New York

29425

RECRUITING

Medical University of South Carolina, Charleston

All Listed Sponsors
collaborator

United States Department of Defense

FED

collaborator

Medical University of South Carolina

OTHER

lead

Columbia University

OTHER