A Study Comparing IBI362 vs Semaglutide in Chinese Overweight or Obese Adults With Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD)

PHASE3RecruitingINTERVENTIONAL
Enrollment

470

Participants

Timeline

Start Date

May 9, 2025

Primary Completion Date

December 31, 2026

Study Completion Date

June 30, 2027

Conditions
OverweightMetabolic Dysfunction-associated Fatty Liver Disease (MAFLD)
Interventions
DRUG

IBI362

Once-weekly injections of gradually increased doses of IBI362, subcutaneously (SC): starting dose is 2.0 mg, after 4 weeks of administration, increase to 4.0 mg; After another 4 weeks, increase to 6mg; After another 4 weeks, increase to the maximum dose 9mg for 36 weeks

DRUG

semaglutide

Once-weekly injections of gradually increased doses, subcutaneously (SC): starting dose is 0.25 mg, after 4 weeks of administration, increase to 0.5 mg; After another 4 weeks, increase to 1mg; After another 4 weeks, increase to 1.7mg; After another 4 weeks, increase to the maximum 2.5mg for 32 weeks

Trial Locations (1)

100730

RECRUITING

Beijing Hospital, Beijing

All Listed Sponsors
lead

Innovent Biologics (Suzhou) Co. Ltd.

INDUSTRY

NCT06884293 - A Study Comparing IBI362 vs Semaglutide in Chinese Overweight or Obese Adults With Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) | Biotech Hunter | Biotech Hunter