Efficacy and Safety of Sintilimab Combined with Platinum-containing Double-agent Chemotherapy in First-line Treatment of Locally Advanced or Metastatic Non-small Cell Lung Cancer in Elderly Patients

Enrolling by invitationOBSERVATIONAL
Enrollment

43

Participants

Timeline

Start Date

March 12, 2025

Primary Completion Date

May 30, 2026

Study Completion Date

June 29, 2027

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Sintilimab+Cis-platinum/Carboplatin with Pemetrexed or Gemcitabine

"1. Sintilimab, 200mg, intravenous infusion on day 1 of each cycle, every 3 weeks as a cycle (Q3W), until disease progression, death, intolerable toxicity, withdrawal of informed consent, initiation of new anti-tumor therapy, or termination of treatment for other reasons specified in the protocol; The longest treatment time of sintilimab was 24 months.~2. Chemotherapy regimen:~1\) Pemetrexed combined with platinum regimen (non-squamous cell carcinoma) : pemetrexed 500mg/m2, intravenous infusion on day 1 of each cycle, cisplatin 75mg/m2 or carboplatin AUC 5, intravenous infusion on day 1 of each cycle, every 3 weeks (Q3W) for a total of 4-6 cycles.~2\) Gemcitabine plus platinum regimen (squamous cell carcinoma) : gemcitabine 1000mg/m2 intravenously on days 1 and 8 of each cycle, cisplatin 75mg/m2 or carboplatin: AUC 5, intravenous infusion on day 1 of each cycle, every 3 weeks (Q3W) for 4-6 cycles."

Trial Locations (2)

250014

Degan Lu, Jinan

The First Affiliated Hospital of Shandong First Medical University, Jinan

All Listed Sponsors
lead

Qianfoshan Hospital

OTHER