NCT06881771View on ClinicalTrials.gov

FECD-TRACE: Fuchs' Endothelial Corneal Dystrophy TRAjectory and Correlation With Genotype in the United Kingdom

RecruitingOBSERVATIONAL
Enrollment

500

Participants

Timeline

Start Date

February 1, 2024

Primary Completion Date

February 1, 2026

Study Completion Date

February 1, 2027

Conditions
Fuchs DystrophyFuchs' Endothelial DystrophyFuchs' Endothelial Corneal Dystrophy of Bilateral EyesCorneal Dystrophy FuchsCorneal Dystrophy
Interventions
DIAGNOSTIC_TEST

Clinical phenotyping

"* Visual acuity assessment~* Contrast sensitivity evaluation~* Slit-lamp photography~* Specular microscopy~* Scheimpflug tomography~* Anterior segment optical coherence tomography~* In vivo confocal microscopy~* Spatio-temporal optical coherence tomography"

GENETIC

CTG18.1 Expansion Status Genotyping

"Genotyping for trinucleotide repeat in the TCF4 gene (CTG18.1) and other genetic biomarkers using blood or saliva derived genomic DNA. This includes:~* Short tandem repeat - PCR~* Triplet-repeat primed - PCR~* Genome-wide single nucleotide polymorphism genotyping~* Ultra-deep locus-specific next-generation sequencing"

Trial Locations (1)

EC1V 9EL

RECRUITING

University College London, London

All Listed Sponsors
lead

University College, London

OTHER