Iparomlimab and Tuvonralimab Combined With Paclitaxel and Cisplatin as Neoadjuvant Therapy for CC

PHASE2RecruitingINTERVENTIONAL
Enrollment

35

Participants

Timeline

Start Date

March 15, 2025

Primary Completion Date

March 31, 2028

Study Completion Date

March 31, 2030

Conditions
Cervical Cancers
Interventions
DRUG

Neoadjuvant Chemotherapy

paclitaxel, 135-175mg/m2, q3w, 3 cycles

DRUG

Neoadjuvant Chemotherapy

cisplatin, 75-80mg/m2, q3w, 3 cycles

DRUG

Immunotherapy

Iparomlimab and Tuvonralimab, 5mg/kg, q3w, 3cycles

PROCEDURE

Radical surgery

After 3 cycles of neoadjuvant therapy, patients who achieved CR/PR will undergo radical hysterectomy plus lymphadenectomy

PROCEDURE

Fertility-preserving surgery

After 3 cycles of neoadjuvant therapy, patients who achieved CR/PR will undergo Fertility-preserving surgery. For stage IB1/IB2 patients, conization or simple trachelectomy plus lymphadenectomy will be performed. For stage IIA1/IIA2 patients, radical trachelectomy plus lymphadenectomy will be performed.

Trial Locations (1)

Unknown

RECRUITING

The Obstetrics & Gynecology Hospital of Fudan University, Shanghai

All Listed Sponsors
lead

Obstetrics & Gynecology Hospital of Fudan University

OTHER