35
Participants
Start Date
March 15, 2025
Primary Completion Date
March 31, 2028
Study Completion Date
March 31, 2030
Neoadjuvant Chemotherapy
paclitaxel, 135-175mg/m2, q3w, 3 cycles
Neoadjuvant Chemotherapy
cisplatin, 75-80mg/m2, q3w, 3 cycles
Immunotherapy
Iparomlimab and Tuvonralimab, 5mg/kg, q3w, 3cycles
Radical surgery
After 3 cycles of neoadjuvant therapy, patients who achieved CR/PR will undergo radical hysterectomy plus lymphadenectomy
Fertility-preserving surgery
After 3 cycles of neoadjuvant therapy, patients who achieved CR/PR will undergo Fertility-preserving surgery. For stage IB1/IB2 patients, conization or simple trachelectomy plus lymphadenectomy will be performed. For stage IIA1/IIA2 patients, radical trachelectomy plus lymphadenectomy will be performed.
RECRUITING
The Obstetrics & Gynecology Hospital of Fudan University, Shanghai
Obstetrics & Gynecology Hospital of Fudan University
OTHER