Thrombolysis in Factor Xa-inhibitors Trial

PHASE3RecruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

March 14, 2025

Primary Completion Date

December 31, 2028

Study Completion Date

December 31, 2037

Conditions
StrokeStroke (in Patients With Atrial Fibrillation)Ischemic StrokeAcute Ischemic StrokeAnticoagulant TherapyFactor Xa InhibitorIntracranial HemorrhagesHemorrhagic Transformation Due to Acute StrokeBleeding in the Brain
Interventions
DRUG

thrombolysis therapy

All treatment and monitoring routines are according to the hospitals' standard operating procedures (SOP), and both drugs (Alteplase (ALP) and Tenecteplase (TNK)) are approved drugs for the indication AIS with similar efficacy and safety profile. SIFT is designed to test the hypothesis that intravenous thrombolysis (IVT) (tenecteplase 0.25 mg/kg or alteplase 0.9 mg/kg intravenously) is efficient and safe in acute ischemic stroke patients (AIS) with recent ingestion (last 48 hours) of an Factor Xa (FXa) inhibitor who otherwise are eligible for IVT.

Trial Locations (13)

1346

RECRUITING

Dept. of Medicine, Baerum Hospital, Bærum

1714

RECRUITING

Dept of Neurology, Ostfold Hospital Trust, Kalnes, Grålum

2609

RECRUITING

Dept of Neurology, Innlandet Hospital Trust, Lillehammer, Lillehammer

3004

RECRUITING

Dept of Neurology, Drammen Hospital Trust, Drammen

3103

RECRUITING

Dept of Neurology, Vesfold Hospital Trust, Tonsberg, Tønsberg

4011

RECRUITING

Dept of Neurology, Stavanger University Hospital, Stavanger

4615

RECRUITING

Dept of Neurology, Hospital of Southern Norway, SSHF, Kristiansand

5009

RECRUITING

Dept of Medicine, Haraldsplass deaconal Hospital, Bergen

RECRUITING

Dept. Of Neurology, Haukeland University Hopsital, Bergen

6017

RECRUITING

Dept of Medicine, Helse More and Romsdal Health Trust, Aalesund Hospital, Ålesund

7030

RECRUITING

Dept. Of Medicine, St.Olav Hospital, Trondheim, Trondheim

9019

RECRUITING

Dept. of Neurology, Tromso University Hospital, Tromsø

0450

RECRUITING

Dept. of Neurology, Oslo University Hospital, Oslo

All Listed Sponsors
collaborator

Klinbeforsk

OTHER

collaborator

Clinical Trial Unit (CTU), Oslo University Hospital

UNKNOWN

lead

Guri Hagberg

OTHER