National Cohort of Subjects at Risk of Developing Rheumatoid Arthritis

A total of 60 ml of blood will be collected while fasting, using the following tubes: one PAXGene Blood RNA Tube, one PAXGene Blood DNA Tube, five 5 mL serum tubes, five 5 mL EDTA tubes and one 2 mL EDTA tube for microbiota DNA analysis.

Urine will be collected, while fasting and after the administration of lactulose/ mannitol to assess intestinal permeability.

Stool samples will be collected either at the hospital or at home using a dedicated kit.

5 ml of saliva will be collected and saliva microbiome DNA will be collected using an OMNIgene Oral kit.

inhalation of salbutamol, measurement of peak expiratory flow by screening spirometry (15 min later), inhalation of a hypertonic aerosol for 3 periods of 7 min. At the end of each inhalation period, the induced sputum is collected and the peak expiratory flow is measured to prevent possible bronchospasms

Hair and nails samples will be collected.

To assess of tear secretion

To assess the risk of RA in high-risk subjects by evaluating for synovitis, tenosynovitis, or intermetatarsal-phalangeal bursitis.

MRI of the dominant or painful hand will be performed to assess the risk of RA in high-risk subjects.

Self-questionnaires will assess factors such as ethnic origin, family history of RA, diet, physical activity, exposure to toxic substances, pollution, occupational exposures, psychological and clinical factors.

Performed as part of routine care to assess dental health

The short-CTQ will be completed during this consultation, only in centers offering consultations with a psychologist.

The patient will wear a belt throughout the visit 1. At the end of the day, the heart rate variability data measured by the belt will be recorded in the CRF (RR interval, heart rate variability SDNN, RMSSD, and LF/HF sympathovagal balance).