Comparative Study of Adjuvant Therapy for Postoperative Cervical Gastric-type Adenocarcinoma

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

238

Participants

Timeline

Start Date

March 31, 2025

Primary Completion Date

December 31, 2029

Study Completion Date

December 31, 2030

Conditions
Gastric-type Endocervical AdenocarcinomaCervical Cancer
Interventions
DRUG

paclitaxel and platinum

After the start of External Beam Radiation Therapy (EBRT), paclitaxel (150-175 mg/m2) or paclitaxel (albumin-bound) 222-260 mg/m2 + cisplatin (60-75 mg/m2) or carboplatin \[Area Under Curve (AUC) = 4-5\], Q3W (every 3 weeks is a dosing cycle), administered on the first day of each cycle, for a total of 4 cycles. Adjuvant chemotherapy started 4 weeks after the end of external irradiation therapy, and chemotherapy-related adverse reactions dropped to grade 2 or below before chemotherapy began. If not met, it can be postponed for 2 weeks.

DRUG

platinum

During EBRT, cisplatin (40 mg/m2) or carboplatin (AUC = 2) was used for concurrent chemotherapy once a week for a total of 5 times. On the day of cisplatin infusion, radiotherapy should be performed after cisplatin or carboplatin.

All Listed Sponsors
lead

Women's Hospital School Of Medicine Zhejiang University

OTHER