36,000
Participants
Start Date
March 12, 2025
Primary Completion Date
July 1, 2026
Study Completion Date
July 1, 2026
Dihydroartemisinin piperaquine
Taken orally. 11 kg to less than 17 kg 1 tablet per day for 3 days 40 mg 320 mg 17 kg to less than 25 kg 1½ tablets per day for 3 days 60 mg 480 mg 25 kg to less than 36 kg 2 tablets per day for 3 days 80 mg 640 mg 36 kg to less than 60 kg 3 tablets per day for 3 days 120 mg 960 mg 60 kg to less than 80 kg 4 tablets per day for 3 days 160 mg 1280 mg 80 kg or more 5 tablets per day for 3 days 200 mg 1600 mg For patients weighing less than 11 kg, alternative formulations supplying lower amounts of active substance should be preferred
Dihydroartemisinin piperaquine + Bacillus thuringiensis israelensis
Study staff will provide adult participant with LLIN(s), DP and with an 8-oz packet of Bti, a pair of latex gloves, a teaspoon, and a tracking form. A staff member will then survey an area (50 m radius) around the house and demonstrate appropriate application in up to 5 potential breeding sites.
Long-lasting Insecticidal Net
Distribution of Long-lasting Insecticidal Net to all households on the study.
Mbarara University of Science and Technology (MUST), Mbarara
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
North Carolina State University
OTHER
Mbarara University of Science and Technology
OTHER
University of North Carolina, Chapel Hill
OTHER