IGHID 12334 - After the Flood: Optimal Strategies to Prevent Malaria Epidemics Caused by Severe Flooding

NAActive, not recruitingINTERVENTIONAL
Enrollment

36,000

Participants

Timeline

Start Date

March 12, 2025

Primary Completion Date

July 1, 2026

Study Completion Date

July 1, 2026

Conditions
Malaria InfectionMalaria Falciparum
Interventions
DRUG

Dihydroartemisinin piperaquine

Taken orally. 11 kg to less than 17 kg 1 tablet per day for 3 days 40 mg 320 mg 17 kg to less than 25 kg 1½ tablets per day for 3 days 60 mg 480 mg 25 kg to less than 36 kg 2 tablets per day for 3 days 80 mg 640 mg 36 kg to less than 60 kg 3 tablets per day for 3 days 120 mg 960 mg 60 kg to less than 80 kg 4 tablets per day for 3 days 160 mg 1280 mg 80 kg or more 5 tablets per day for 3 days 200 mg 1600 mg For patients weighing less than 11 kg, alternative formulations supplying lower amounts of active substance should be preferred

COMBINATION_PRODUCT

Dihydroartemisinin piperaquine + Bacillus thuringiensis israelensis

Study staff will provide adult participant with LLIN(s), DP and with an 8-oz packet of Bti, a pair of latex gloves, a teaspoon, and a tracking form. A staff member will then survey an area (50 m radius) around the house and demonstrate appropriate application in up to 5 potential breeding sites.

OTHER

Long-lasting Insecticidal Net

Distribution of Long-lasting Insecticidal Net to all households on the study.

Trial Locations (1)

PO Box 1410

Mbarara University of Science and Technology (MUST), Mbarara

All Listed Sponsors
collaborator

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

collaborator

North Carolina State University

OTHER

collaborator

Mbarara University of Science and Technology

OTHER

lead

University of North Carolina, Chapel Hill

OTHER

NCT06870344 - IGHID 12334 - After the Flood: Optimal Strategies to Prevent Malaria Epidemics Caused by Severe Flooding | Biotech Hunter | Biotech Hunter