A Multicenter Phase II Clinical Study of Neoadjuvant Use of Camrelizumab in Combination With Chemotherapy for Organ Preservation in Esophageal Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

283

Participants

Timeline

Start Date

April 30, 2025

Primary Completion Date

December 31, 2029

Study Completion Date

December 31, 2029

Conditions
Esophageal Cancer
Interventions
DRUG

Camrelizumab + Nab-paclitaxel + Cisplatin

Three cycles of neoadjuvant therapy with camrelizumab (200 mg/dose D1, IV, Q3W)+Nab-paclitaxel(260 mg/m2 D1,IV,Q3W)+Cisplatin(75 mg/m2 D1,IV,Q3W); for patients with organ preservation intent entered into the watchful waiting strategy group and received radiotherapy (50.4 Gy/28 doses), with camrelizumab maintenance therapy for 4-12 weeks after the end of radiotherapy, and a total of up to one year of camrelizumab.

Trial Locations (1)

100142

RECRUITING

Peking University Cancer Hospital, Beijing

All Listed Sponsors
lead

Peking University Cancer Hospital & Institute

OTHER