50
Participants
Start Date
September 22, 2025
Primary Completion Date
December 1, 2027
Study Completion Date
April 1, 2029
fludarabine
30 mg/m2 per day IV on days -5, -4, -3, -2
cyclophosphamide
500 mg/m2 per day IV on days -4, -3, -2
cetuximab
"Participants Age \>=18 years, based on FDA approved dosing: Loading dose of 400 mg/m2 IV, followed by 250 mg/m2 IV weekly for a total of 4 doses.~Participants Age \<18 years, based on phase I data of cetuximab in children: Dose of 250 mg/m2 IV administered over 1 hour weekly for a total of 4 doses."
FGFR4-CAR T Cells
Single intravenous (IV) infusion on Day 0
RECRUITING
National Institutes of Health Clinical Center, Bethesda
National Cancer Institute (NCI)
NIH