A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

206

Participants

Timeline

Start Date

April 10, 2025

Primary Completion Date

January 9, 2026

Study Completion Date

March 6, 2026

Conditions
Hypertension
Interventions
DRUG

Tonlamarsen

Tonlamarsen will be administered subcutaneously (SC) every 4 weeks during the randomized part of the study

DRUG

Placebo

Placebo will be administered subcutaneously (SC) every 4 weeks during the randomized part of the study

Trial Locations (39)

10310

Richmond University Medical Center, Staten Island

10455

CHEAR Center LLC, The Bronx

20110

Manassas Clinical Research Center, Manassas

23504

York Clinical Research LLC, Norfolk

28645

IMA Clinical Research, Lenoir

29461

Clinical Trials of South Carolina, Moncks Corner

30328

Agile Clinical Research Trials, LLC, Atlanta

31406

Velocity Clinical Reseach, Savannah

32127

Progressive Medical Research, Port Orange

32216

Jacksonville Center for Clinical Research, Jacksonville

33033

Homestead Associates in Research, Inc., Homestead

34652

Suncoast Clinical Research, Inc., New Port Richey

35216

Achieve Clinical Research, LLC, Birmingham

36207

Pinnacle Research Group, Anniston

37660

Holston Medical Group, Kingsport

38654

Olive Branch Family Medical Center, Olive Branch

48085

Oakland Medical Research Center, Troy

57702

Health Concepts, Rapid City

60031

Clinical Investigation Specialists, Inc., Gurnee

60621

Eagle Clinical Research, Chicago

61550

Koch Family Medicine Clinical Research, Morton

70072

Tandem Clinical Research GI, LLC, Marrero

70115

DelRicht Clinical Research - New Orleans, New Orleans

71201

IMA Clinical Research, Monroe

72204

Cardiology and Medicine Clinic, Little Rock

76180

North Hills Medical Research, North Richland Hills

76550

Radiance Clinical Research, Lampasas

77040

Juno Research, LLC, Houston

77459

Synergy Groups Medical, LLC, Missouri City

78215

Sun Research Institute, San Antonio

78628

Advanced Medical Trials, LLC, Georgetown

78705

Central Texas Clinical Research, Austin

85018

Elite Clinical Studies, Phoenix

85715

Del Sol Research Management, LLC, Tucson

90017

American Institute of Research, Los Angeles

92024

North Coast Cardiology, Encinitas

92630

Orange County Research Center, Lake Forest

95648

Clinical Trials Research, Lincoln

01844

ActivMed Practices & Research, LLC, Methuen

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Kardigan, Inc.

INDUSTRY

NCT06864104 - A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL) | Biotech Hunter | Biotech Hunter