Neural Representations of Memory Transformation (MEM_TRANS)

Not yet recruitingOBSERVATIONAL
Enrollment

40

Participants

Timeline

Start Date

December 1, 2025

Primary Completion Date

March 31, 2026

Study Completion Date

March 31, 2026

Conditions
Healthy Older Adults
Interventions
BEHAVIORAL

Computer-based visuomotor sequence learning and interference

The behavioral sequence learning and interference paradigm allows the experimental manipulation of sequence memory after long-term consolidation achieved through individualized longitudinal practice and serves the extraction of the primary behavioral outcome. The learning task requires participants to respond with keypresses on a standard computer keyboard of visual targets. Participants will implicitly (without being made aware) learn sequential regularities provided through the recurring order of cued keys contrasted with random keys. Participants will practice the learning task remotely over consecutive days until a stable performance plateau is reached. During this phase, data will be collected online, and behavioral change will be monitored in real time. Then participants will undergo the behavioral interference intervention, in which the initially learned sequence memory will be perturbed through (implicit) exposure to new sequential information (i.e., interference).

All Listed Sponsors
collaborator

National Institutes of Health (NIH)

NIH

lead

Medical University of South Carolina

OTHER

NCT06862622 - Neural Representations of Memory Transformation (MEM_TRANS) | Biotech Hunter | Biotech Hunter