Effectiveness and Safety of InO±DLI for Relapsed B-ALL/LBL After Allo-HSCT

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

23

Participants

Timeline

Start Date

March 1, 2025

Primary Completion Date

April 30, 2026

Study Completion Date

April 30, 2027

Conditions
Leukemia, Lymphocytic, Acute
Interventions
DRUG

Inotuzumab Ozogamicin±Donor Lymphocyte Infusion

"Participants will receive Ino±DLI regimen:~* ① InO induction dose: the first cycle: 0.8mg/m2, intravenous infusion, d1; 0.5 mg/m2, intravenous infusion, d8, d15;~* ② If CR/CRi was reached after induction, the second cycle :0.5mg/m2, intravenous infusion, d1, d8,d15; If CR/CRi is not reached, Cycle 2 :0.8mg/m2, IV infusion, d1; 0.5 mg/m2, intravenous infusion, d8, d15;~* ③DLI dose: CD3 positive cells 1x10\^7/kg; DLI indication: no previous grade III-IV aGVHD, negative HLALOSS test and no present aGVHD and cGVHD;~* Lumbar puncture: cytarabine 50mg+dexamethasone 5mg+methotrexate 10mg, intrathecal injection, once a month after remission, a total of 4-6 courses of treatment."

Trial Locations (1)

Unknown

The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou

All Listed Sponsors
lead

First Affiliated Hospital of Zhejiang University

OTHER