Embryonal Tumor With Multilayered Rosettes

PHASE2RecruitingINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

March 6, 2025

Primary Completion Date

September 30, 2030

Study Completion Date

March 31, 2032

Conditions
Embryonal Tumor With Multilayered RosettesEmbryonal Tumor With Multilayered Rosettes, Nos
Interventions
RADIATION

Radiotherapy (RT)

Undergo RT

DRUG

Chemotherapy Drug, Cancer - Physician's Choice

One or more of the following may be assigned by the physician (physician's choice) per standard of care guidelines upon study enrollment following surgery: Cytarabine, Carboplatin, Cisplatin, Vincristine Sulfate injection (Vincristine PFS), Topotecan Hydrochloride, Dactinomycin, Thiotepa, Filgrastim, Cyclophosphamide, or Doxorubicin Hydrochloride. Not all participants will receive all possible drug regimens.

PROCEDURE

Non-Investigational Surgical Resection

Undergo surgery directly before study enrollment as part of planned care.

DRUG

Temozolomide

Participants assigned to or whom receive optional RT will receive concurrent temozolomide

PROCEDURE

Tumor Tissue Sample

Tumor tissue will be collected for correlative studies

PROCEDURE

Blood Sample

Blood samples will be collected for correlative studies

PROCEDURE

Cerebrospinal Fluid (CSF) Sample

CSF samples will be collected for correlative studies

Trial Locations (2)

21218

RECRUITING

Johns Hopkins University, Baltimore

94143

RECRUITING

University of California, San Francisco, San Francisco

All Listed Sponsors
collaborator

Pediatric Neuro-Oncology Consortium

OTHER

collaborator

Solving Kids' Cancer

OTHER

lead

University of California, San Francisco

OTHER