70
Participants
Start Date
March 6, 2025
Primary Completion Date
September 30, 2030
Study Completion Date
March 31, 2032
Radiotherapy (RT)
Undergo RT
Chemotherapy Drug, Cancer - Physician's Choice
One or more of the following may be assigned by the physician (physician's choice) per standard of care guidelines upon study enrollment following surgery: Cytarabine, Carboplatin, Cisplatin, Vincristine Sulfate injection (Vincristine PFS), Topotecan Hydrochloride, Dactinomycin, Thiotepa, Filgrastim, Cyclophosphamide, or Doxorubicin Hydrochloride. Not all participants will receive all possible drug regimens.
Non-Investigational Surgical Resection
Undergo surgery directly before study enrollment as part of planned care.
Temozolomide
Participants assigned to or whom receive optional RT will receive concurrent temozolomide
Tumor Tissue Sample
Tumor tissue will be collected for correlative studies
Blood Sample
Blood samples will be collected for correlative studies
Cerebrospinal Fluid (CSF) Sample
CSF samples will be collected for correlative studies
RECRUITING
Johns Hopkins University, Baltimore
RECRUITING
University of California, San Francisco, San Francisco
Pediatric Neuro-Oncology Consortium
OTHER
Solving Kids' Cancer
OTHER
University of California, San Francisco
OTHER