This Study Will Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of MET097 in Adult Participants With Overweight or Obesity

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

262

Participants

Timeline

Start Date

April 1, 2024

Primary Completion Date

January 3, 2025

Study Completion Date

May 31, 2025

Conditions
Obesity and Overweight
Interventions
BIOLOGICAL

(Part C) MET097

"Participants will receive 13 once-weekly subcutaneous injections of MET097 as follows:~* 12 once-weekly doses of 0.6mg followed by a 13th dose of 1.2mg~* 12 once-weekly doses of 0.6mg followed by a 13th dose of 2.4 mg~* 12 once-weekly doses of 0.8 mg followed by a 13th dose of 1.6 mg~* 12 once-weekly doses of 0.8 mg followed by a 13th dose of 3.2 mg~* 12 once-weekly doses of 1.0 mg followed by a 13th dose of 2.0 mg~* 12 once-weekly doses of 1.0 mg followed by a 13th dose of 4.0 mg~* 12 once-weekly doses of 1.2 mg followed by a 13th dose of 2.4 mg~* 12 once-weekly doses of 1.2 mg followed by a 13th dose of 4.8 mg~* Titration regimen of 0.4mg/0.8mg/1.2mg with 4 doses at each dose-level, followed by a 13th dose of 2.4mg~* Titration regimen of 0.4mg/0.8mg/1.2mg with 4 doses at each dose-level, followed by a 13th dose of 4.8mg"

BIOLOGICAL

(Part C) Placebo

Participants will receive 13 once-weekly subcutaneous injections of matching placebo

Trial Locations (3)

66212

Research Site MET097 23-101-001, Overland Park

90630

Research Site MET097 23-101-003, Cypress

92801

Research Site MET097 23-101-002, Anaheim

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Metsera

INDUSTRY

NCT06857617 - This Study Will Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of MET097 in Adult Participants With Overweight or Obesity | Biotech Hunter | Biotech Hunter