A Megastudy of Single-Session Interventions for Depression

NACompletedINTERVENTIONAL
Enrollment

7,505

Participants

Timeline

Start Date

March 11, 2025

Primary Completion Date

June 24, 2025

Study Completion Date

June 24, 2025

Conditions
Depression - Major Depressive Disorder
Interventions
BEHAVIORAL

Behavioral Activation (Action Brings Change Project 10-Minute Version)

"A behavioral activation SSI where users learn about negative thought spirals, give advice to an imagined peer, then create an action plan of helpful activities to do in the near future. This is a shorter version of the original 15-minute Action Brings Change SSI."

BEHAVIORAL

Mindful Acceptance

A clinical psychologist explains a few ways to use mindful acceptance to deal with difficult thoughts and feelings.

BEHAVIORAL

Moral Elevation

Users learn about moral elevation, then watch a touching video where a man does good deeds for people in his community (originally a Thai life insurance advertisement). Finally, they plan a positive action they can take to help others in their own life.

BEHAVIORAL

Mindful Attention Skills

A series of videos teach mindfulness skills: how to release thoughts and re-evaluate negative interpretations.

BEHAVIORAL

5 Habits to Beat Depression

A clinical psychologist and science communicator describes his top 5 one-minute habits to beat depression.

BEHAVIORAL

Interactive Cognitive Reappraisal

An interactive SSI where participants learn how to reframe negative thoughts

BEHAVIORAL

Expressive Writing (AI-supported)

Participants describe a negative thought they struggle with and an LLM helps them to consider a story in which a peer overcomes that thought.

BEHAVIORAL

Inner Child Healing Walk

An interactive journey to reconnect and heal one's inner child through breathing exercises, positive affirmations, and supportive animal companions.

BEHAVIORAL

Savoring Strategies

An SSI introducing savoring strategies to improve mood.

BEHAVIORAL

Personalized Intervention Recommender

Identifies the kinds of depression one struggles most with and offers a personalized recommendation for future depression support options

BEHAVIORAL

Dialectical Behavioral Therapy Skills

Presents videos from dialectical behavioral therapy on various ways to control negative emotions.

BEHAVIORAL

All about Trout

An 8-10 minute educational program with information and interactive exercises about trout fish. Intended to capture one's attention and require some effort, while minimizing influence on depressive symptoms.

BEHAVIORAL

Reframing Negative Thoughts

An audio-only program in which users are guided to reflect on how they might challenge negative automatic thoughts and beliefs they struggle with.

Trial Locations (1)

60611

Northwestern University Medical Social Sciences, Chicago

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

lead

Northwestern University

OTHER

NCT06856668 - A Megastudy of Single-Session Interventions for Depression | Biotech Hunter | Biotech Hunter