Double Dose 4-AP on Functional Recovery After Spinal Cord Injury

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

27

Participants

Timeline

Start Date

February 1, 2025

Primary Completion Date

March 31, 2026

Study Completion Date

March 31, 2026

Conditions
SCI - Spinal Cord Injury
Interventions
DRUG

Dalfampridine

The study drug (4-AP) will be administered as a 10 mg dose twice a day.

DRUG

Placebo

The placebo provided by the SRAL pharmacy that looks identical to the 4-AP, will be administered twice a day.

OTHER

STDP stimulation

Paired stimulation will be given to the spinal cord and to peripheral nerves so that the signals are received at the spinal cord at a specific interval.

BEHAVIORAL

Exercise training

Lower-limb exercises will involve over-ground walking, treadmill, walking and stair climbing training.

Trial Locations (1)

60611

RECRUITING

Shirley Ryan Abilitylab, Chicago

All Listed Sponsors
lead

Shirley Ryan AbilityLab

OTHER