Empirical Intravenous Beta-Lactam Plus Metronidazole Vs Oral Cefixime Plus Metronidazole for the Treatment of Liver Abscess

PHASE3RecruitingINTERVENTIONAL
Enrollment

220

Participants

Timeline

Start Date

February 25, 2025

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2026

Conditions
Liver Abscess
Interventions
DRUG

Intravenous beta-lactam antimicrobial for 2 weeks Plus Intravenous Metronidazole (750 mg q 8 hourly) for 2 weeks

Intravenous beta-lactam antimicrobial for 2 weeks Plus Intravenous Metronidazole (750 mg q 8 hourly) for 2 weeks and standard care

DRUG

Tablet Cefixime (200 mg q 12 hourly) for 2 weeks Plus Tablet Metronidazole (800 mg q 8 hourly) for 2 weeks

Tablet Cefixime (200 mg q 12 hourly) for 2 weeks Plus Tablet Metronidazole (800 mg q 8 hourly) for 2 weeks

OTHER

Standard medical care

Percutaneous drainage or aspiration of the abscess along resuscitative and symptomatic medications

Trial Locations (1)

160012

RECRUITING

Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh

All Listed Sponsors
lead

Post Graduate Institute of Medical Education and Research, Chandigarh

OTHER