A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003)

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

280

Participants

Timeline

Start Date

April 15, 2025

Primary Completion Date

March 27, 2029

Study Completion Date

March 27, 2029

Conditions
Ovarian Cancer Recurrent
Interventions
BIOLOGICAL

Raludotatug Deruxtecan

IV infusion on Day 1 of every 3-week cycle.

DRUG

Carboplatin

IV infusion on Day 1 of every 3-week cycle for a maximum of 6 cycles.

DRUG

Paclitaxel

IV infusion on Day 1 of every 3-week cycle for a maximum of 6 cycles.

BIOLOGICAL

Bevacizumab

IV infusion on Day 1 of every 3-week cycle.

DRUG

Rescue Medication

Includes 5-HT3 Serotonin Receptor Antagonist, NK-1 receptor antagonist, and corticosteroid, administered per protocol.

BIOLOGICAL

Pembrolizumab

IV infusion on Day 1 of every 3-week cycle for a maximum of 35 cycles.

Trial Locations (15)

10065

RECRUITING

Memorial Sloan Kettering Cancer Center ( Site 0003), New York

22908

RECRUITING

University of Virginia Health System ( Site 0011), Charlottesville

28027

RECRUITING

Clinica Universidad de Navarra ( Site 0301), Madrid

28040

RECRUITING

Hospital Universitario Fundación Jiménez Díaz-START Madrid-FJD ( Site 0303), Madrid

28041

RECRUITING

Hospital Universitario 12 de Octubre ( Site 0304), Madrid

40202

RECRUITING

The University of Louisville, James Graham Brown Cancer Center ( Site 0009), Louisville

77030

RECRUITING

Houston Methodist Hospital ( Site 0010), Houston

84119

RECRUITING

START Mountain Region ( Site 0008), West Valley City

3109601

RECRUITING

Rambam Health Care Campus ( Site 0202), Haifa

5265601

RECRUITING

Sheba Medical Center ( Site 0200), Ramat Gan

9103102

RECRUITING

Shaare Zedek Medical Center ( Site 0201), Jerusalem

08908

RECRUITING

Institut Català d'Oncologia - L'Hospitalet ( Site 0302), L'Hospitalet de Llobregat

08035

RECRUITING

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 0300), Barcelona

SW3 6JJ

RECRUITING

Royal Marsden Hospital ( Site 0402), Fulham

SM2 5PT

RECRUITING

The Royal Marsden NHS Foundation Trust. ( Site 0403), Sutton

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Daiichi Sankyo

INDUSTRY

lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT06843447 - A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003) | Biotech Hunter | Biotech Hunter