Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury

NARecruitingINTERVENTIONAL
Enrollment

5

Participants

Timeline

Start Date

April 1, 2025

Primary Completion Date

November 30, 2026

Study Completion Date

November 30, 2026

Conditions
Spinal Cord Injuries (SCI)Orthostatic Hypotension, DysautonomicCardiovascularTranscutaneous Spinal Stimulation
Interventions
DEVICE

spinal cord transcutaneous stimulation

"Stimulation, using the Neostim-5 (Cosyma Ltd.), a 5-channel electrical stimulator, will be administered throughout the study period, beginning shortly after the injury and continuing at regular intervals until one year post-spinal cord injury. It will be performed in two settings:~1. During seated mapping to identify stimulation sites (potentially T7/8, T11/12, L1/2, and S1/2) and determine stimulation parameters (e.g., frequency, pulse wave, amplitude) that elevate systolic blood pressure (SBP) and maintain it within the target range of 110-120 mmHg.~2. During 70-degree tilt tests to elicit an orthostatic response (a drop in blood pressure accompanied by symptoms)."

Trial Locations (1)

07052

RECRUITING

Kessler Foundation, West Orange

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Kessler Foundation

OTHER