60
Participants
Start Date
March 12, 2025
Primary Completion Date
August 31, 2026
Study Completion Date
August 31, 2026
Propranolol (Beta-Blocker) and Etodolac (COX-2 Inhibitor)
"\- Intervention Arm: Propranolol (Beta-Blocker) and Etodolac (COX-2 Inhibitor). Name: Propranolol (slow-Release) and Etodolac.~Propranolol Dosage Schedule:~5 days pre-surgery: 20mg twice daily (BID), Day of surgery: 80mg BID,~1-week Post-surgery: 40mg BID, week 2-11 post-surgery: 20mg BID.~Etodolac Dosage Schedule:~5 days pre-surgery until 3 weeks post-surgery: 400mg BID.~Administration Route: Oral."
Placebo (Matching for Propranolol & Etodolac)
\- Placebo Arm: Placebo (Matching for Propranolol \& Etodolac). Inert placebo tablets matching propranolol and etodolac in appearance and dosing schedule. Administration Route: Oral.
RECRUITING
The Chaim Sheba Medical Center, Ramat Gan
RECRUITING
Tel Aviv Sourasky Medical Center (Ichilov Hospital), Tel Aviv
National Cancer Institute (NCI)
NIH
The Chaim Sheba Medical Center
OTHER
Tel-Aviv Sourasky Medical Center
OTHER_GOV