Novel Allogenic CD19-targeting CAR-γδT Cell Therapy (QH103E) in r/r NHL

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

July 27, 2025

Primary Completion Date

March 1, 2027

Study Completion Date

March 1, 2028

Conditions
Non-hodgkin Lymphoma,B Cell
Interventions
BIOLOGICAL

Allogenic CD19-CAR-γδT cell

Phase 1 dose escalation (3+3) : dose 1 (1 × 10\^6 cells/kg) , dose 2 (3 × 10\^6 cells/kg), dose 3 (6× 10\^6 cells/kg); Phase 2 : dose of RP2D.

DRUG

Fludarabine

"Intravenous fludarabine 30\~50 mg/m\^2/day on days~-5, -4, and -3."

DRUG

Cyclophosphamide

Intravenous cyclophosphamide 500\~1000 mg/m\^2/ day on days -5, -4, and -3.

Trial Locations (1)

100853·

RECRUITING

Biotherapeutic Department of Chinsese PLA Gereral Hospital, Beijing

All Listed Sponsors
lead

Chinese PLA General Hospital

OTHER

NCT06838832 - Novel Allogenic CD19-targeting CAR-γδT Cell Therapy (QH103E) in r/r NHL | Biotech Hunter | Biotech Hunter