Volatility in Paranoia (VIP) Trial: An RCT of Changes in Volatility With Psychotherapy

NARecruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

January 15, 2025

Primary Completion Date

September 3, 2029

Study Completion Date

February 1, 2030

Conditions
Schizophrenia Disorders
Interventions
BEHAVIORAL

Cognitive Behavioral Therapy

Individuals will be assessed for which psychological factors are maintaining paranoia in their daily lives. They will collaboratively identify one maintenance factor to focus on (e.g. worry, anomalous experience, self-confidence, PTSD) for 8 weeks of individual therapy. Then, all participants will transition to 8 weeks of individual therapy focused on dropping safety behaviors and re-engaging in everyday life.

BEHAVIORAL

TAU

Individuals will continue treatment as usual (TAU). In addition they will have contact with a study therapist weekly via phone to provide information on what treatment they received. Phone check-ins will last approximately 5-10 minutes.

Trial Locations (1)

37212

RECRUITING

Vanderbilt University Medical Center, Nashville

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

lead

Vanderbilt University Medical Center

OTHER