NCT06835491View on ClinicalTrials.gov

Prophylactic Anti-aRrhythmic Therapy with Amiodarone in Critically Ill Patients Admitted for an Out-of-hospital Cardiac Arrest with Initial Shockable Rhythm

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

674

Participants

Timeline

Start Date

June 15, 2025

Primary Completion Date

January 15, 2027

Study Completion Date

March 15, 2027

Conditions
Ventricular Arrhythmias and Cardiac Arrest
Interventions
DRUG

Amiodarone

Initial loading dose of 300mg over 30 minutes in 250ml of glucose 5% solution. Continuous amiodarone infusion will be administered for 72 hours at a dose of 10 mg/kg without exceeding 900 mg/24h.

Trial Locations (29)

Unknown

Chu Amiens, Amiens

Chu Angers, Angers

CH annecy genevois, Annecy

Ch Argenteuil, Argenteuil

CH Mondor, Aurillac

CHU Brest, Brest

CH Brive, Brive-la-Gaillarde

Chu Caen, Caen

Chi Nord Ardennes, Charleville-Mézières

CHSF, Corbeil-Essonnes

CHD vendée, La Roche-sur-Yon

CH la rochelle, La Rochelle

Hcl, Lyon

Ap Hm, Marseille

Hopital Cartier, Massy

chi Gregoire, Montreuil

Hoptial Mulhouse, Mulhouse

CHU Nantes, Nantes

Clinique Ambroise Paré, Neuilly-sur-Seine

CHU Nice -MIR Archet, Nice

CHU Nice -MIR Pasteur, Nice

Chu Orléans, Orléans

CHU Cochin, Paris

Hopital saint joseph, Paris

CHU Poitiers, Poitiers

Chu Strasbourg, Strasbourg

CHI Toulon, Toulon

Chu Toulouse, Toulouse

CH Cotentin, Valognes

All Listed Sponsors
lead

Versailles Hospital

OTHER