CAR2219 CAR-T Cells for the Treatment of R/R B Cell Leukemia and Lymphoma

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

January 20, 2025

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2027

Conditions
Relapsed or Refractory B Cell Leukemia and Lymphoma
Interventions
GENETIC

CAR2219-T cells

"Genetic: CAR2219-T cells Each subject will be infused with single dose of CD2219-CAR-T cells. A classic 3+3 dose escalation will be employed. The low dose is 5×10\^5 /kg, the medium dose is 1×10\^6 /kg, and the high dose is 2×10\^6 /kg.~Drug: Fludarabine Fludarabine will be given at a dose of 30 mg/m2/day intravenously (IV) for 3 days prior to the infusion of CD2219-CAR-T cells.~Drug: Cyclophosphamide Cyclophosphamide will be given at a dose of 300 mg/m2/day intravenously (IV) for 3 days prior to the infusion of CD2219-CAR-T cells."

Trial Locations (1)

Unknown

RECRUITING

the Fifth Medical Center of Chinese People's Liberation Army General Hospital, Beijing

All Listed Sponsors
lead

Affiliated Hospital to Academy of Military Medical Sciences

OTHER