CAR2219 CAR-T Cells for the Treatment of R/R B Cell Leukemia and Lymphoma

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

January 20, 2025

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2027

Conditions
Relapsed or Refractory B Cell Leukemia and Lymphoma
Interventions
GENETIC

CAR2219-T cells

"Genetic: CAR2219-T cells Each subject will be infused with single dose of CD2219-CAR-T cells. A classic 3+3 dose escalation will be employed. The low dose is 5×10\^5 /kg, the medium dose is 1×10\^6 /kg, and the high dose is 2×10\^6 /kg.~Drug: Fludarabine Fludarabine will be given at a dose of 30 mg/m2/day intravenously (IV) for 3 days prior to the infusion of CD2219-CAR-T cells.~Drug: Cyclophosphamide Cyclophosphamide will be given at a dose of 300 mg/m2/day intravenously (IV) for 3 days prior to the infusion of CD2219-CAR-T cells."

Trial Locations (1)

Unknown

RECRUITING

the Fifth Medical Center of Chinese People's Liberation Army General Hospital, Beijing

All Listed Sponsors
lead

Affiliated Hospital to Academy of Military Medical Sciences

OTHER

NCT06834529 - CAR2219 CAR-T Cells for the Treatment of R/R B Cell Leukemia and Lymphoma | Biotech Hunter | Biotech Hunter