NCT06834126View on ClinicalTrials.gov

Papaverine in Combination With Radiation Therapy for the Treatment of Locally Advanced Rectal Cancer, DINOMITE Trial

PHASE1RecruitingINTERVENTIONAL
Enrollment

36

Participants

Timeline

Start Date

April 7, 2025

Primary Completion Date

September 19, 2028

Study Completion Date

September 19, 2028

Conditions
Locally Advanced Rectal AdenocarcinomaStage II Rectal Cancer AJCC v8Stage III Rectal Cancer AJCC v8
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood and tissue sample collection

PROCEDURE

Computed Tomography

Undergo CT

DRUG

Consolidation Therapy

Receive CC with mFOLFOX6 or CAPOX

PROCEDURE

Functional Magnetic Resonance Imaging

Undergo fMRI

PROCEDURE

Gastrointestinal Endoscopy

Undergo endoscopy

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Papaverine

Given IV

RADIATION

Radiation Therapy

Undergo RT

PROCEDURE

Total Mesorectal Excision

Undergo ToME

Trial Locations (1)

91010

RECRUITING

City of Hope Medical Center, Duarte

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

City of Hope Medical Center

OTHER