NCT06832085 - Combination Nicotine Replacement Therapy, Cytisine, or Varenicline for Smoking Cessation | Biotech Hunter

Enrollment

1,500

Participants

Timeline

Start Date

April 30, 2025

Primary Completion Date

August 31, 2026

Study Completion Date

December 31, 2026

Conditions

Tobacco

Interventions

DRUG

Nicotine Replacement Therapy (Nicotine patch plus NRT gum or lozenge)

Participants in this group will apply 1 NRT patch each morning for up to 26 weeks. Patches will be titrated based on cigarettes consumed. Short-acting NRT products (gum and lozenge) will be used as needed by the participants in this group.

DRUG

Cytisine

Participants in this group will take 3mg of cytisine 3 times per day for 12 weeks.

DRUG

Varenicline (Champix)

Participants in this group will take 1mg of varenicline 2 times per day for 12 weeks.

Trial Locations (1)

K1Y 4W7

RECRUITING

University of Ottawa Heart Institute, Ottawa