Clinical Trial of TQB2825 Injection Combined Immunochemotherapy in Subjects With Diffuse Large B Cell Lymphoma

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

April 23, 2025

Primary Completion Date

March 31, 2026

Study Completion Date

December 31, 2026

Conditions
Diffuse Large B Cell Lymphoma
Interventions
DRUG

TQB2825 injection +R-CHOP regimen

"R-CHOP is a cancer treatment regimen that uses a combination of five drugs to treat non-Hodgkin lymphoma, e.g., Rituximab+Cyclophosphamide+Doxorubicin Hydrochloride+Vincristine+Prednisone (R-CHOP).~TQB2825 Injection: TQB2825 is a bispecific antibody targeting the cluster of differentiation 20 (CD20) receptor on tumor cells and the cluster of differentiation 3 (CD3) receptor on T cells.~Rituximab: A monoclonal antibody that binds to the CD20 antigen on the surface of B cells.~Cyclophosphamide: An alkylating agent that inhibits the synthesis of DNA and proteins in cancer cells.~Doxorubicin Hydrochloride: An antineoplastic antibiotic that inhibits the synthesis of DNA and RNA.~Vincristine: A microtubule inhibitor that blocks the normal function of microtubules during cell division.~Prednisone: A corticosteroid drug with anti-inflammatory, anti-allergic, immunosuppressive, and anti-cancer effects.~TQB2825 injection + GemOx (Gemcitabine + Oxaliplatin)"

DRUG

TQB2825 injection + GemOx

"TQB2825 Injection: TQB2825 is a bispecific antibody targeting the CD20 receptor on tumor cells and the CD3 receptor on T cells.~Gemcitabine: A nucleoside analog that inhibits DNA synthesis. Oxaliplatin: A platinum-based chemotherapy drug that forms cross-links with DNA, inhibiting DNA replication and transcription."

Trial Locations (25)

26400

NOT_YET_RECRUITING

Yantai Yuhuangding Hospital, Yantai

30000

NOT_YET_RECRUITING

Shanxi Cancer hospital, Taiyuan

100142

RECRUITING

Beijing Cancer Hospital, Beijing

116000

NOT_YET_RECRUITING

The second Hospital of dalian, Dalian

130021

NOT_YET_RECRUITING

The First Hospital of Jilin University, Changchun

150081

NOT_YET_RECRUITING

Harbin Medical University Cancer Hospital, Harbin

200032

NOT_YET_RECRUITING

Fudan university shanghai cancer center, Shanghai

210000

NOT_YET_RECRUITING

Jiangsu Provincial People's Hospital, Nanjing

221000

NOT_YET_RECRUITING

The Affiliated Hospital of Xuzhou Medical University, Xuzhou

233000

NOT_YET_RECRUITING

The First Affiliated Hospital of Bengbu Medical College, Bengbu

243000

RECRUITING

Maanshan People's Hospital, Ma’anshan

250117

NOT_YET_RECRUITING

Affiliated Cancer Hospital of Shandong First Medical University, Jinan

300000

NOT_YET_RECRUITING

People's Hospital of Tianjin (City), Tianjin

300060

NOT_YET_RECRUITING

Tianjin Medical University Cancer Hospital, Tianjin

330029

NOT_YET_RECRUITING

Jiangxi Canser Hospital, Nanchang

350014

NOT_YET_RECRUITING

Fujian Cancer Hospital, Fuzhou

362000

RECRUITING

The Second Affiliated Hospital of Fujian Medical University, Quanzhou

430079

NOT_YET_RECRUITING

Hubei Cancer Hospital, Wuhan

457000

RECRUITING

Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou

457001

NOT_YET_RECRUITING

Puyang Oilfield General Hospital, Puyang

510000

NOT_YET_RECRUITING

Sun Yat-sen University Cancer Center, Guangzhou

545006

NOT_YET_RECRUITING

Liuzhou People's Hospital, Liuzhou

646000

NOT_YET_RECRUITING

The Affiliated Hospital of Southwest Medical University, Luzhou

710000

NOT_YET_RECRUITING

The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an

730000

NOT_YET_RECRUITING

Gansu Provincial Cancer Hospital, Lanzhou

All Listed Sponsors
lead

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

INDUSTRY