"Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer"

PHASE2RecruitingINTERVENTIONAL
Enrollment

52

Participants

Timeline

Start Date

February 11, 2025

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2027

Conditions
MCRC
Interventions
DRUG

Thymalfasin (Thymosin alpha 1, Ta1)

Thymalfasin: 4.8 mg, administered subcutaneously twice weekly.

DRUG

Regorafenib (BAY 73-4506)

Regorafenib: Start at 80 mg once daily, orally, taken at a fixed time for 2 consecutive weeks and then stopped for 1 week. If the patient tolerates it well, increase to 120 mg/d in Cycle 2.

DRUG

Tislelizumab (BGB-A317)

Tislelizumab: 200 mg, iv.gtt, single infusion, 21 days as a cycle, Day 1.

Trial Locations (1)

100050

RECRUITING

Beijing Friendship Hospital, Capital Medical University, Beijing

All Listed Sponsors
collaborator

Peking Union Medical College Hospital

OTHER

collaborator

Peking University People's Hospital

OTHER

lead

Beijing Friendship Hospital

OTHER