A Study to Evaluate the Impact of Mosunetuzumab Consolidation for Older Patients With Diffuse Large B-cell Lymphoma (DLBCL) Who Have Detectable Amounts of ctDNA (Circulating Tumor DNA) at the End of Treatment With Pola-R-mini-CHP

PHASE2RecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

September 4, 2025

Primary Completion Date

April 1, 2029

Study Completion Date

April 30, 2030

Conditions
Diffuse Large B-Cell Lymphoma (DLBCL)
Interventions
DRUG

Mosunetuzumab

Mosunetuzumab consolidation therapy will consist of 6 cycles of IV mosunetuzumab at the standard ramp-up dosing (Day 1 1mg, Day 8 2mg, D15 60mg, C2D1 60mg, and 30mg on day 1 of the subsequent 21-day cycles)

DEVICE

ClonoSEQ

Patients with detectable ClonoSEQ at C6D1 who have a PET/CT that shows a CR will receive mosunetuzumab

Trial Locations (1)

14642

RECRUITING

Wilmot Cancer Institute, Rochester

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

collaborator

Adaptive Biotechnologies

INDUSTRY

collaborator

Lymphoma Research Foundation

OTHER

lead

Danielle Wallace

OTHER