Intravenous Methadone Versus Intrathecal Morphine for Analgesia Following Cesarean Delivery

PHASE4RecruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

February 12, 2025

Primary Completion Date

September 30, 2025

Study Completion Date

November 7, 2025

Conditions
Cesarean Delivery
Interventions
DRUG

Intravenous line (IV) Methadone

"Subjects will receive standardized spinal anesthesia without intrathecal morphine (intrathecal 1.6-2 mL 0.75% bupivacaine + dextrose, 15 mcg fentanyl) and intravenous methadone (0.2mg/kg total body weight up to max dose of 20 mg, with saline added to make total volume 2 mL)~The Intravenous line (IV) methadone will be administered after cord clamping and administration of uterotonics with the dose of medication divided into 4 equal aliquots each administered 5 minutes apart."

DRUG

Intrathecal Morphine

"Subjects will receive standardized spinal anesthesia with intrathecal morphine 150 micrograms and no methadone (2cc dose of IV normal saline)~The Intravenous line (IV) saline will be administered after cord clamping and administration of uterotonics with the dose of medication divided into 4 equal aliquots each administered 5 minutes apart."

Trial Locations (1)

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Mayo Clinic

OTHER

NCT06826742 - Intravenous Methadone Versus Intrathecal Morphine for Analgesia Following Cesarean Delivery | Biotech Hunter | Biotech Hunter