A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)

PHASE3RecruitingINTERVENTIONAL
Enrollment

770

Participants

Timeline

Start Date

April 9, 2025

Primary Completion Date

April 27, 2029

Study Completion Date

October 15, 2032

Conditions
Ovarian CancerFallopian Tube CancerPrimary Peritoneal Cancer
Interventions
BIOLOGICAL

Sacituzumab tirumotecan

IV Infusion

BIOLOGICAL

Bevacizumab

IV Infusion

DRUG

H1 receptor antagonist

Rescue medication taken per approved product label before sacituzumab tirumotecan

DRUG

H2 receptor antagonist

Rescue medication taken per approved product label before sacituzumab tirumotecan

DRUG

Acetaminophen (or equivalent)

Rescue medication taken per approved product label before sacituzumab tirumotecan

DRUG

Dexamethasone (or equivalent)

Rescue medication taken per approved product label before sacituzumab tirumotecan

DRUG

Steroid mouthwash (dexamethasone or equivalent)

Rescue medication taken orally 4 times daily

Trial Locations (30)

104

RECRUITING

Mackay Memorial Hospital ( Site 2604), Taipei

704

RECRUITING

National Cheng Kung University Hospital ( Site 2602), Tainan City

2148

RECRUITING

Blacktown Hospital ( Site 0211), Sydney

3002

RECRUITING

Epworth Freemasons ( Site 0217), East Melbourne

3199

RECRUITING

Frankston Hospital ( Site 0216), Frankston

4120

RECRUITING

Gallipoli Medical Research Ltd ( Site 0214), Brisbane

10408

RECRUITING

National Cancer Center ( Site 2305), Goyang-si

14004

RECRUITING

Hospital Universitario Reina Sofia ( Site 2406), Córdoba

17007

RECRUITING

Institut Català d'Oncologia (ICO) - Girona ( Site 2402), Girona

28027

RECRUITING

Clinica Universidad de Navarra ( Site 2407), Madrid

28034

RECRUITING

Hospital Ramon y Cajal ( Site 2405), Madrid

34239

RECRUITING

Sarasota Memorial Hospital ( Site 0075), Sarasota

39216

ACTIVE_NOT_RECRUITING

St. Dominic's Hospital ( Site 0064), Jackson

40705

RECRUITING

Taichung Veterans General Hospital ( Site 2603), Taichung

45219

RECRUITING

University of Cincinnati Medical Center ( Site 0090), Cincinnati

68114

RECRUITING

Nebraska Methodist Hospital ( Site 0053), Omaha

74146

RECRUITING

Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0056), Tulsa

08901

RECRUITING

Rutgers Cancer Institute of New Jersey ( Site 0071), New Brunswick

02905

RECRUITING

Women & Infants Hospital ( Site 0050), Providence

830-0011

RECRUITING

Kurume University Hospital ( Site 1640), Kurume

350-1298

RECRUITING

Saitama Medical University International Medical Center ( Site 1632), Hidaka

135-8550

RECRUITING

Cancer Institute Hospital of JFCR ( Site 1639), Koto

160-8582

RECRUITING

Keio University Hospital ( Site 1636), Shinjyuku

951-8566

RECRUITING

Niigata Cancer Center Hospital ( Site 1633), Niigata

03722

RECRUITING

Severance Hospital ( Site 2302), Seodaemun-Gu

05505

RECRUITING

Asan Medical Center ( Site 2304), Songpa-gu

03080

RECRUITING

Seoul National University Hospital ( Site 2301), Seoul

06351

RECRUITING

Samsung Medical Center ( Site 2303), Seoul

08035

RECRUITING

Hospital Vall D Hebron ( Site 2403), Barcelona

08907

RECRUITING

ICO L Hospitalet ( Site 2408), Barcelona

All Listed Sponsors
collaborator

European Network of Gynaecological Oncological Trial Groups (ENGOT)

OTHER

collaborator

GOG Foundation

NETWORK

lead

Merck Sharp & Dohme LLC

INDUSTRY