Impact of PEEP Trials on Ventilation-Perfusion Matching in ARDS Patients

PHASE2/PHASE3Enrolling by invitationINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

November 1, 2022

Primary Completion Date

November 1, 2025

Study Completion Date

November 1, 2025

Conditions
ARDS
Interventions
DRUG

10ml of 10% saline is injected centrally

"The first phase of the study is an observational study that does not alter the clinical treatment plan.~The experimental group(Sample size of 48 cases) in the second phase of the study needs to receive a central venous injection of 10ml of 10% saline to demonstrate pulmonary blood flow, while the control group (Sample size of 48 cases)requires no intervention.~The experimental group select the optimal pulmonary blood flow PEEP By Electrical impedance tomography.Change in ventilation-perfusion ratio measured by EIT during PEEP trials from baseline to 30 minutes at each PEEP level (5, 10, 15 cmH2O).~The control group was selected Best PEEP according to the PEEP table ."

Trial Locations (1)

200025

Department of Critical Care Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China., Shanghai

All Listed Sponsors
lead

Ruijin Hospital

OTHER