Furazolidone Quadruple Regimen Eradicate H. Pylori Infection

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

493

Participants

Timeline

Start Date

August 1, 2022

Primary Completion Date

July 30, 2024

Study Completion Date

July 30, 2024

Conditions
Helicobacter Pylori InfectionEradication
Interventions
DRUG

Furazolidone

esomeprazole magnesium 20 mg bid +colloidal bismuth pectin 200mg bid + amoxicillin 1000 mg bid + furazolidone 100 mg bid, for 14 days. After stopping the medication for 30 days, check the H. pylori again. If H. pylori is negative, check again after 6 months and 12 months, the experiment stop. If H. pylori is positive, check again after 6 months. If H. pylori is still positive, high-dose dual therapy will be used to resist H. pylori again. After stopping the second medication for 30 days, check the H. pylori again. If H. pylori is negative, check again after 6 months, and the experiment stops. If H. pylori is still positive, check again after 6 months, and the experiment stops.

DRUG

Clarithromycin

esomeprazole magnesium 20 mg bid +colloidal bismuth pectin 200mg bid + amoxicillin 1000 mg bid + clarithromycin 500 mg bid, for 14 days. After stopping the medication for 30 days, check the H. pylori again. If H. pylori is negative, check again after 6 months and 12 months, the experiment stop. If H. pylori is positive, check again after 6 months. If H. pylori is still positive, high-dose dual therapy will be used to resist H. pylori again. After stopping the second medication for 30 days, check the H. pylori again. If H. pylori is negative, check again after 6 months, and the experiment stops. If H. pylori is still positive, check again after 6 months, and the experiment stops.

Trial Locations (1)

252000

Liaocheng Peoples hospital, Liaocheng

All Listed Sponsors
lead

Liaocheng People's Hospital

OTHER