Immunogenicity and Safety PCV-20 of the Vaccine Administered During an Acute Febrile Illness in Adults

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

1,052

Participants

Timeline

Start Date

October 31, 2025

Primary Completion Date

January 1, 2027

Study Completion Date

January 1, 2028

Conditions
Acute Febrile IllnessPneumococcal Infections
Interventions
BIOLOGICAL

Early intervention

"In this arm, patient will receive unique dose of the PCV-20 vaccine (Prevnar 20) as soon as possible and until 72h after apyrexia.~The Prevenar 20 will be used Prevenar 20 will be injected by intramuscular route. The preferred site of injection is the deltoid muscle of the upper arm in adults."

BIOLOGICAL

Delayed intervention

"In this arm, from 15 days and until 58 days after fever resolution (i.e after the first day with a body temperature \< 37.5°C without paracetamol use in the 6 previous hours) (whether or not the patient has been discharged) in the absence of fever, the patient will receive unique dose of the PCV-20 vaccine (Prevnar 20).~The Prevenar 20 will be used Prevenar 20 will be injected by intramuscular route. The preferred site of injection is the deltoid muscle of the upper arm in adults."

Trial Locations (24)

21000

Centre Hospitalier Universitaire, Dijon

25000

Centre Hospitalier Universitaire, Besançon

29609

Centre Hospitalier Universitaire, Brest

Centre Hospitalier, Brest

30029

Centre Hospitalier Universitaire, Nîmes

33000

Centre Hospitalier, Bordeaux

34295

Centre Hospitalier Regional Universitaire, Montpellier

35000

Centre Hospitalier Universitaire, Rennes

38043

Centre Hospitalier Universitaire, Grenoble

42055

CHU de Saint-Etienne, Saint-Etienne

43000

Centre Hospitalier, Le Puy-en-Velay

44093

Centre Hospitalier Universitaire, Nantes

54511

Centre Hospitalier Universitaire, Nancy

59037

Centre Hospitalier Universitaire, Lille

69004

Hospices Civils de Lyon, Lyon

72000

Centre Hospitalier General, Le Mans

73011

Centre Hospitalier General Metropole Savoie, Chambéry

74000

Centre Hospitalier, Annecy

75012

Centre Hospitalier Bichat, Paris

75679

Assistance Publique Hopitaux de Paris, Paris

76000

Centre Hospitalier Universitaire, Rouen

85925

Centre Hospitalier, La Roche-sur-Yon

94000

Centre Hospitalier de Creteil, Créteil

06202

Centre Hospitalier Universitaire, Nice

All Listed Sponsors
collaborator

Ministry of Health, France

OTHER_GOV

lead

Centre Hospitalier Universitaire de Saint Etienne

OTHER