PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

3,100

Participants

Timeline

Start Date

October 31, 2025

Primary Completion Date

August 31, 2029

Study Completion Date

December 31, 2029

Conditions
All-cause MortalityQuality of LifeDisability, IntellectualNeurological DisorderAcute Brain InjuryVentilation, MechanicalIntensive Care Medicine
Interventions
DRUG

Ceftriaxone 2g diluted in >200ml 0.9%sodium chloride

2 grams of Ceftriaxone diluted in \>200ml of 0.9%sodium chloride are administered intravenously once following randomisation

DRUG

Placebo comparator - no ceftriaxone

placebo: \>200ml 0.9% sodium chloride given as an intravenous infusion once after randomisation

Trial Locations (9)

2000

Royal North Shore Hospital, Sydney

The George Institute, Sydney

2217

St George Hospital, Kogarah

2747

Nepean Hospital, Kingswood

4006

Royal Brisbane and Women's Hospital, Herston

4102

Princess Alexandra Hospital, Woolloongabba

6150

Fiona Stanley Hospital, Perth

Unknown

The Alfred Hospital, Melbourne

Wellington Hospital, Wellington

All Listed Sponsors
lead

The George Institute

OTHER