Individualized Functional Imaging-Guided Repetitive Transcranial Magnetic Stimulation (rTMS) for Treating Postural Gait Disorders in Patients with Amyotrophic Lateral Sclerosis (ALS): a Randomized, Crossover, Controlled, Double-Blind Clinical Study

EARLY_PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

February 14, 2025

Primary Completion Date

March 15, 2026

Study Completion Date

March 15, 2026

Conditions
Amyotrophic Lateral Sclerosis (ALS)
Interventions
DEVICE

Transcranial Magnetic Stimulation

Patients in Group A will receive 2 weeks (10800 Hz daily, 5 days×2) of TMS treatment, while patients in Group B will receive sham stimulation with the same frequency. After a 4-week washout period, the two groups cross over. Patients in Group A will receive sham stimulation, and patients in Group B will receive TMS treatment for 2 weeks (10800 Hz daily, 5 days×2).

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Changping Laboratory

OTHER

lead

Peking University Third Hospital

OTHER

NCT06819358 - Individualized Functional Imaging-Guided Repetitive Transcranial Magnetic Stimulation (rTMS) for Treating Postural Gait Disorders in Patients with Amyotrophic Lateral Sclerosis (ALS): a Randomized, Crossover, Controlled, Double-Blind Clinical Study | Biotech Hunter | Biotech Hunter