Comparing CPAP and BiPAP for Sleep-Disordered Breathing in People with Cervical Spinal Cord Injuries

NANot yet recruitingINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

August 1, 2025

Primary Completion Date

September 1, 2026

Study Completion Date

September 1, 2027

Conditions
Spinal Cord Injuries (SCI)Sleep Disordered Breathing (SDB)Sleep ApneaCervical Spinal Cord Injruy
Interventions
DEVICE

CPAP

Participants randomized to this group will receive auto-CPAP therapy. The device will be initiated by a respiratory therapist at GF Strong Rehabilitation Centre. Settings will be adjusted to achieve a device efficacy index \< 5 events per hour.

DEVICE

BiPAP

Participants will receive BiPAP S mode therapy for 4 weeks. The device will be initiated by a respiratory therapist at GF Strong Rehabilitation Centre with initial settings of IPAP 8 cmH2O and EPAP 3 cmH2O. Settings will be modified to a maximum tolerated level to achieve a tidal volume of 8 mL/kg ideal body weight and SpO2 \> 95%. Overnight oximetry will be performed to ensure at least 4 hours of device use, and settings will be adjusted to achieve a DEI \< 5 events per hour.

Trial Locations (1)

V5Z 2G9

GF Strong Rehabilitation Centre, Vancouver

All Listed Sponsors
lead

University of British Columbia

OTHER

NCT06818604 - Comparing CPAP and BiPAP for Sleep-Disordered Breathing in People with Cervical Spinal Cord Injuries | Biotech Hunter | Biotech Hunter