Safety, Tolerability and Efficacy of Adjunctive TBO-309 in Reperfusion for Stroke With Tandem Occlusion

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

78

Participants

Timeline

Start Date

October 1, 2025

Primary Completion Date

December 30, 2026

Study Completion Date

December 31, 2026

Conditions
Ischemic StrokeTandem Occlusion
Interventions
DRUG

TBO-309: 60 mg

TBO-309 is a potent, selective and ATP competitive PI3Kβ inhibitor which blocks platelet activation adhesion/aggregation and promotes platelet disaggregation. By targeting PI3Kβ, TBO-309 specifically inhibits thrombosis whilst minimizing the impact on normal haemostasis.

DRUG

TBO-309: 120 mg

TBO-309 is a potent, selective and ATP competitive PI3Kβ inhibitor which blocks platelet activation adhesion/aggregation and promotes platelet disaggregation. By targeting PI3Kβ, TBO-309 specifically inhibits thrombosis whilst minimizing the impact on normal haemostasis.

DRUG

TBO-309: 30 mg

TBO-309 is a potent, selective and ATP competitive PI3Kβ inhibitor which blocks platelet activation adhesion/aggregation and promotes platelet disaggregation. By targeting PI3Kβ, TBO-309 specifically inhibits thrombosis whilst minimizing the impact on normal haemostasis.

Trial Locations (2)

2065

Royal North Shore Hospital, St Leonards

2305

John Hunter Hospital, Newcastle

All Listed Sponsors
lead

ThromBio Pty. Ltd.

INDUSTRY