PD-1 Inhibitors Maintenance for cHL Post-autoHCT

PHASE2RecruitingINTERVENTIONAL
Enrollment

83

Participants

Timeline

Start Date

September 2, 2024

Primary Completion Date

September 30, 2029

Study Completion Date

September 30, 2030

Conditions
Hodgkin Lymphoma
Interventions
DRUG

Nivolumab, Pembrolizumab

"The choice of drug and its dose for maintenance therapy is at the discretion of the study centre (e.g. nivolumab, pembrolizumab). Maintenance therapy should be initiated no later than 60 days after D0, exceptions may be made due to reasonable justification in consultation with the Study PI and will not be considered a protocol deviation.~Nivolumab maintenance therapy regimens:~* Nivolumab (40 mg, fixed dose) IV D1 of each 14-days cycle up to 12 cycles~* Nivolumab (3 mg/kg) IV D1 of each 14-days cycle up to 12 cycles~Pembrolizumab maintenance therapy regimen:~-Pembrolizumab (200 mg, fixed dose) IV D1 of each 21-days cycle up to 8 cycles"

Trial Locations (3)

Unknown

RECRUITING

National Research Oncology Center, Astana

RECRUITING

National Medical and Surgical Center named after N.I. Pirogov, Moscow

RECRUITING

RM Gorbacheva Research Institute, Pavlov University, Saint Petersburg

All Listed Sponsors
lead

St. Petersburg State Pavlov Medical University

OTHER