A Study of VRC07-523LS, PGT121.414.LS, and PGDM1400LS Broadly Neutralizing Monoclonal Antibodies Given Intravenously in Adult Participants Without HIV

PHASE2RecruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

March 7, 2025

Primary Completion Date

January 15, 2027

Study Completion Date

September 15, 2027

Conditions
HIV
Interventions
BIOLOGICAL

VRC07-523LS 400mg

Intravenous infusion (IV)

BIOLOGICAL

PGT121.414.LS 400mg

IV infusion

BIOLOGICAL

PGDM1400LS 400mg

IV infusion

BIOLOGICAL

VRC07-523LS 3200mg

IV infusion

BIOLOGICAL

PGT121.414.LS 1600mg

IV infusion

BIOLOGICAL

PGDM1400LS 1600mg

IV infusion

Trial Locations (20)

1

NOT_YET_RECRUITING

ACSA CRS, Iquitos

1862

NOT_YET_RECRUITING

Perinatal HIV Research Unit (PHRU), Johannesburg

4030

NOT_YET_RECRUITING

Chatsworth CRS, Chatsworth

7925

NOT_YET_RECRUITING

Groote Schuur HIV CRS, Cape Town

10032

RECRUITING

Columbia P&S CRS, New York

15001

NOT_YET_RECRUITING

Via Libre, Lima

15081

NOT_YET_RECRUITING

Citbm Crs, Callao

15213

NOT_YET_RECRUITING

University of Pittsburgh CRS (Site 1001), Pittsburgh

19104

RECRUITING

Penn Prevention CRS, Philadelphia

27599

RECRUITING

Chapel Hill CRS (Site #3201), Chapel Hill

30030

RECRUITING

The Hope Clinic of the Emory Vaccine Research Center; Emory University, Decatur

35222

RECRUITING

Alabama CRA (Site #31788), Birmingham

37232

RECRUITING

Vanderbilt Vaccine (VV) CRS, Nashville

94102

RECRUITING

Bridge HIV, San Francisco Department of Public Health, San Francisco

98104

RECRUITING

Seattle Vaccine and Prevention CRS (Site ID# 30331), Seattle

02115-6110

RECRUITING

Brigham and Women's Hospital Vaccine CRS (BWH VCRS), Boston

02215-4302

NOT_YET_RECRUITING

Fenway Health, Boston

02215

RECRUITING

BIDMC VCRS (Site ID# 32077), Boston

21040-360

NOT_YET_RECRUITING

Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS, Rio de Janeiro

0152

NOT_YET_RECRUITING

Setshaba Research Centre, Soshanguve-H

All Listed Sponsors
collaborator

National Institutes of Health (NIH)

NIH

collaborator

Department of Health and Human Services

FED

collaborator

Dale and Betty Bumpers Vaccine Research Center (VRC)

UNKNOWN

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH