Two-cycle and Three-cycle Induction Therapy With Modified TPF Regimen Combined and Camrelizumab for LANPC

PHASE2RecruitingINTERVENTIONAL
Enrollment

208

Participants

Timeline

Start Date

February 25, 2025

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2029

Conditions
Nasopharyngeal NeoplasmsPD-1 InhibitorInduction TherapyComplete ResponseChemotherapy
Interventions
DRUG

Two-cycle induction chemotherapy + immunotherapy

Two cycles of nab-paclitaxel at 260 mg/m2 on day 1, cisplatin at 25 mg/m2 from days 1 to 3, and oral S1 twice daily from days 1 to 14 (40 mg twice daily on patients with a body surface area \[BSA\] less than 1.25 m2, 50 mg twice daily for patients with a BSA between 1.25 and 1.5 m2, and 60 mg twice daily for patients with a BSA \>1.5 m2). Camrelizumab was administered intravenously at a dose of 200 mg on the first day of each cycle.

DRUG

Three-cycle induction chemotherapy + immunotherapy

Three cycles of nab-paclitaxel at 260 mg/m2 on day 1, cisplatin at 25 mg/m2 from days 1 to 3, and oral S1 twice daily from days 1 to 14 (40 mg twice daily on patients with a body surface area \[BSA\] less than 1.25 m2, 50 mg twice daily for patients with a BSA between 1.25 and 1.5 m2, and 60 mg twice daily for patients with a BSA \>1.5 m2). Camrelizumab was administered intravenously at a dose of 200 mg on the first day of each cycle.

Trial Locations (3)

361003

RECRUITING

The First Affiliated Hospital of Xiamen University, Xiamen

363099

RECRUITING

Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou

570311

RECRUITING

Hainan General Hospital, Haikou

All Listed Sponsors
lead

The First Affiliated Hospital of Xiamen University

OTHER